Description
🐍 The Venom-Mimetic Peptide — In Its Purest Form
Syn-Ake is a synthetic tripeptide that mimics the mechanism of Waglerin-1, a compound found in the venom of the Temple Viper (Tropidolaemus wagleri). Rather than using actual venom, Syn-Ake replicates its key action at the muscular level — temporarily inhibiting muscle contractions at the neuromuscular junction to visibly smooth expression lines and wrinkles.
Developed by Pentapharm (now DSM), Syn-Ake is one of the most validated and commercially proven peptide actives in cosmetic science. USPowders supplies it at 99% purity in pure powder form for direct formulation use.
✅ Why Formulators Choose Syn-Ake
· Mimics Waglerin-1 to block acetylcholine receptors at the NMJ · Visibly reduces the depth and appearance of expression lines · Targets forehead lines, frown lines, crow’s feet, and perioral wrinkles · Non-toxic, non-invasive alternative to neurotoxin injections · Clinically studied — 52% reduction in wrinkle depth at 4% concentration · Works synergistically with Snap-8 for dual-mechanism anti-wrinkle formulations · Stable in a wide pH range — easy to formulate
📦 Product Specifications
Compound: Dipeptide Diaminobutyroyl Benzylamide Diacetate
INCI Name: Dipeptide Diaminobutyroyl Benzylamide Diacetate
CAS: 823202-99-9
Purity: ≥99% (HPLC verified)
Form: Lyophilized white powder
Appearance: White to off-white powder
Quantity: 1 gram
Solubility: Water-soluble
Recommended pH: 4.0 – 8.0
Suggested Use Level: 1% – 4% in finished formulations
Storage: Cool, dry, away from direct light (room temperature stable)
Grade: Research / Cosmetic Chemistry⚗️ Formulation Notes
Dissolve Syn-Ake in distilled or deionized water before adding to your formulation. It is water-soluble and should be added to the water phase or during cool-down below 40°C. It is stable across a broad pH range (4.0–8.0), making it compatible with most serum and emulsion bases.
Syn-Ake pairs exceptionally well with Snap-8 for a dual-mechanism expression line serum — Snap-8 inhibits SNAP-25 while Syn-Ake targets acetylcholine receptors, delivering two complementary pathways simultaneously. Adding Spilanthes Extract creates a triple-mechanism natural botox alternative serum.
Compatible with hyaluronic acid, niacinamide, GHK-Cu, PDRN, squalane, and most standard cosmetic actives.
💡 How Much Can 1 Gram Make?
At 1% in a 30ml serum: approximately 3 bottles
At 2% in a 30ml serum: approximately 1–2 bottles
At 4% in a 30ml serum: approximately 1 bottleAt the clinically studied 4% concentration, 1 gram yields a full production batch of a 30ml serum.
🔬 The Science Behind It
At the neuromuscular junction, acetylcholine triggers muscle contraction. Syn-Ake’s active dipeptide competes with acetylcholine at the nicotinic receptor, reducing signal transmission and therefore reducing the frequency and force of muscle contraction. The result is a temporary but measurable smoothing of dynamic wrinkles — the same lines caused by repetitive facial expressions over time.
Unlike botulinum toxin, Syn-Ake is topically applied, gradual, and fully reversible. It does not permanently block nerve signals — it modulates them while present in the formulation.
⚠️ Important
For cosmetic and external use in finished formulations only. Not for human consumption or injection. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease or condition. For use by trained formulators and cosmetic professionals. Keep out of reach of children.
🇺🇸 Ships from USA · Research-grade purity · COA available on request
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