If you’re passionate about skincare formulation, anti-aging ingredients, or crafting your own custom serums and creams, Syn-Ake is definitely an ingredient worth exploring.

This advanced peptide has become one of the most talked-about ingredients in cosmetic chemistry thanks to its wrinkle-softening effects and “Botox-like” reputation — all without injections. Let’s take a closer look at Dipeptide Diaminobutyroyl Benzylamide Diacetate, better known as Syn-Ake, and why the 99% pure powder version is so popular among DIY skincare creators.

What Is Syn-Ake?

Syn-Ake is a synthetic peptide inspired by a component found in Temple Viper venom. Despite the inspiration, it’s completely lab-created, cruelty-free, and vegan-friendly.

Its scientific name — Dipeptide Diaminobutyroyl Benzylamide Diacetate — may sound intimidating, but the ingredient itself is highly skin-compatible and easy to formulate with. In its 99% pure powder form, it gives formulators maximum flexibility and control without unnecessary fillers or additives.

Although a 1-gram jar seems small, Syn-Ake is typically used at very low concentrations (around 1–4%), meaning a single jar can create multiple batches of premium anti-aging products. The powder is white, water-soluble, and remains stable when stored correctly.

How Does Syn-Ake Work?

Syn-Ake is designed to help soften the appearance of dynamic wrinkles by relaxing facial tension at the skin’s surface. It works by mimicking a peptide found in snake venom that temporarily reduces the signaling involved in muscle contractions.

The result is smoother-looking skin and reduced appearance of expression lines such as:

• Forehead wrinkles
• Crow’s feet
• Frown lines between the brows

Unlike injectable treatments, Syn-Ake is intended to provide a more subtle, natural-looking effect while still allowing normal facial movement.

Some studies also suggest the peptide may support skin firmness and provide mild antioxidant benefits, making it an appealing multifunctional ingredient for anti-aging formulations.

What Do Studies Show?

Research surrounding Syn-Ake has produced promising results.

In one study involving volunteers using a 4% Syn-Ake cream for 28 days:

• Forehead wrinkle depth was reduced by up to 52%
• Average wrinkle smoothing improvements measured around 20–21%
• Many participants noticed visible improvements around the forehead and eye areas
• Results became more noticeable with continued use

Syn-Ake also combines well with other popular skincare ingredients including hyaluronic acid, niacinamide, and Acetyl Hexapeptide-8 (Argireline), making it ideal for advanced multi-peptide formulas.

Using 99% Pure Syn-Ake Powder in DIY Formulas

For skincare enthusiasts and indie beauty brands, Syn-Ake is surprisingly easy to work with.

Recommended Usage

• Typical concentration: 1–4%
• Beginners may prefer starting around 1–2%

How to Formulate

• Dissolve into the water phase or glycerin phase
• Keep formulation temperatures below 40°C (104°F) when possible
• Recommended pH range: 3.0–5.5
• Add during the cool-down phase of emulsification for best stability

Simple Starter Formula Idea

Try combining:

• 2–3% Syn-Ake
• Hyaluronic acid serum base
• Niacinamide

This creates a lightweight daily serum focused on hydration and visible wrinkle softening.

As always, patch testing and proper stability testing are recommended when creating custom skincare products.

Is Syn-Ake Safe?

Syn-Ake is generally considered well-tolerated for topical cosmetic use and has a strong safety profile when used as directed. Most users experience little to no irritation, though sensitive skin users should always introduce new actives gradually.

Important note: Syn-Ake is intended for external cosmetic use only and should never be injected or consumed internally.

Why Skincare Creators Love It

One of the biggest advantages of 99% pure Syn-Ake powder is the level of customization it offers. Whether you’re formulating for personal use or developing products for a skincare brand, it allows you to create high-performance anti-aging formulas with professional-level ingredients.

It’s modern, science-backed, versatile, and delivers visible cosmetic benefits that many users genuinely notice over time.

Have you experimented with Syn-Ake in your own formulations yet? Pairing it with hydrating ingredients and other peptides can create some incredibly effective skincare combinations.

As always, this article is intended for educational and cosmetic formulation inspiration only. Individual results may vary, and consulting a skincare professional or dermatologist is always recommended for personalized advice.

Happy formulating!

In the ever-evolving world of anti-aging skincare, few ingredients capture the imagination like Syn-Ake. Marketed as a topical alternative to Botox, this synthetic peptide mimics a neurotoxin from the venom of the Temple Viper (Tropidolaemus wagleri). Sold as high-purity Dipeptide Diaminobutyroyl Benzylamide Diacetate powder (99% pure, 1 gram), it empowers cosmetic chemists, formulators, and skincare enthusiasts to create custom anti-wrinkle products with precise control.

What Is Syn-Ake? Origin, Structure, and Purity

Syn-Ake (INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate, CAS 823202-99-9) is a lab-synthesized tripeptide with the sequence H-β-Ala-Pro-Dab-NH-Bzl (as diacetate salt). Its molecular formula is C₂₃H₃₇N₅O₇ and molecular weight ≈495.57 Da—small enough for excellent skin penetration. 

Commercially available as a glycerin-water solution (e.g., SYN®-AKE from DSM-firmenich), the pure 99% powder version offers maximum flexibility for small-batch cosmetic formulation. At just 1 gram, it provides enough active for multiple high-potency creams or serums when used at the recommended 1–4% concentration in final products. The powder is white to off-white, water-soluble, and stable when properly stored.

The Science: How Syn-Ake Works in Cosmetic Chemistry

Unlike collagen-boosting peptides, Syn-Ake targets dynamic (expression) wrinkles caused by repeated facial muscle contractions—forehead lines, crow’s feet, and glabellar furrows.

Mechanism of Action:

• It acts as a reversible antagonist at the muscular nicotinic acetylcholine receptor (mnAChR), specifically the epsilon subunit.
• This blocks acetylcholine binding, preventing sodium ion influx and keeping muscle cells relaxed.
• Result: Reduced muscle contraction frequency and intensity, smoothing wrinkles without paralyzing expression (effects are fast-acting, long-lasting, and fully reversible).

In vitro studies confirm it reduces contraction frequency in innervated muscle cells by up to 82% at 0.5 mM after just 2 hours.

Recent research also highlights additional anti-aging benefits, including interactions with matrix metalloproteinases (MMP-1, -8, -13) and SIRT1 (via in silico docking and MD simulations), plus concentration-dependent antioxidant (DPPH) activity.

Clinical Studies: Proven Wrinkle Reduction

Rigorous human and lab studies back Syn-Ake’s efficacy:

• DSM-firmenich In Vivo Study (45 volunteers, 28 days): A 4% Syn-Ake cream applied twice daily showed:
  • Up to 52% reduction in forehead wrinkle depth (Rt parameter, one volunteer).
  • Average smoothing effect: 21% (Ra) and anti-wrinkle effect: 20% (Rz).
  • Visible results on crow’s feet and forehead; statistically significant (p<0.05 or better) vs. placebo.
  • Smoothing measurable in 80% of volunteers; wrinkle reduction in 73%.

Additional Clinical Data: 4-week use at 4% reduced deep wrinkle appearance significantly. Earlier use demonstrates “age-freezing” effects, delaying new wrinkle formation.

Recent Ex Vivo & Clinical Trials (2026): Serums combining Syn-Ake with acetyl hexapeptide-8 and gluconolactone improved skin biomarkers, texture, and both static/dynamic wrinkles. 

Before-and-after imagery from independent testing often shows noticeable softening of expression lines within 4 weeks.

Formulation Guide: Using 99% Pure Syn-Ake Powder in Cosmetics

The 1-gram 99% pure powder is ideal for DIY or professional cosmetic chemistry:

• Recommended Use Level: 1–4% in the final formulation (higher end for intensive anti-aging serums/creams).
• Solubility: Fully water-soluble; dissolve in the aqueous phase (glycerin or water) at <40°C for best stability.
• pH Stability: Optimal at 3.0–5.5; compatible with ethanol up to 50%.
• Processing: Add at the end of emulsification (cold or warm process, max 70°C for 2 hours).
• Example Calculation: For a 100g batch of cream at 4% active → use 4g of 99% powder (adjust for exact purity).
• Pairing Suggestions: Works synergistically with hyaluronic acid, niacinamide, or other peptides (e.g., Argireline) for multi-action anti-aging formulas.

Stability is excellent (2-year shelf life when sealed). Always perform patch testing and stability testing for custom formulations.

Safety Profile and Considerations

Syn-Ake is considered safe for topical use with a low irritation potential. Standard cosmetic safety testing shows no major concerns; it is vegan-friendly, preservative-free in pure form, and well-tolerated. Rare mild irritation may occur—consult a dermatologist for sensitive skin.

It is not for injection or internal use. The 99% powder is a cosmetic raw material only.

Why Choose 99% Pure Syn-Ake Powder?

This 1-gram jar represents cosmetic chemistry at its finest: high-purity, research-backed, and versatile. Whether formulating professional serums or exploring advanced DIY skincare, Syn-Ake delivers measurable, Botox-like smoothing without needles. Its snake-venom-inspired mechanism continues to inspire new studies on neuromuscular modulation in skincare.

For formulators seeking evidence-based innovation, Syn-Ake remains a standout ingredient—fast, reversible, and proven to help skin look younger while preserving natural expression.Note: Always source cosmetic-grade materials and follow good manufacturing practices. Results vary by individual skin type and formulation.